Nowadays, the so-called explanatory models are a type of modern Nuremberg funnel that facilitates the absorption of knowledge in medical education. Their role is to use simulation games to promote understanding of the causes of clinical symptoms and the diagnosis and treatment of individual diseases in the context of physiological regulation. At the core of medical simulators are mathematical models of physiological systems. Their creation requires multidisciplinary collaboration of highly qualified experts. Thanks to the development of computer technology, educational simulators have become a new market. Today, many companies are involved in developing simulators. Development also occurs in open communities in the academic environment of universities and development companies. Creating and maintaining a community of simulator users and developers is essential.